:: Volume 11, Issue 2 (3-2018) ::
JSS 2018, 11(2): 263-284 Back to browse issues page
Clustering Longitudinal Profiles Using Non-parametric and Semi-parametric Mixed Effects Models
Meysam Tasallizadeh Khemes, Zahra Rezaei Ghahroodi *
Abstract:   (9186 Views)

There are several methods for clustering time course gene expression data. But, these methods have limitations such as the lack of consideration of correlation over time and suffering of high computational. In this paper, by introducing the non-parametric and semi parametric mixed effects model, this correlation over time is considered and by using penalized splines, computation burden dramatically reduced. At the end, using a simulation study the performance of the presented method is compared with previous methods and by using BIC criteria, the most appropriate model is selected. Also the proposed approach is illustrated in a real time course gene expression data set.

Keywords: Longitudinal Profiles, Spline Smoothing, Penalized Spline, Linear Mixed Effects Model, Model- Based Clustering, Gene Expression
Full-Text [PDF 1405 kb]   (3281 Downloads)    
Type of Study: Applied | Subject: Applied Statistics
Received: 2015/04/3 | Accepted: 2016/04/10 | Published: 2016/12/20

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Volume 11, Issue 2 (3-2018) Back to browse issues page