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:: Volume 2, Issue 1 (8-2008) ::
JSS 2008, 2(1): 23-49 Back to browse issues page
Evaluation of Surrogate Endpoints by Bayesian Method
Shohre Jalaei , Soghrat Faghihzadeh * , Farzad Eskandari , Touba Ghazanfari
Abstract:   (5650 Views)
Part of the recent literature on the evaluation of surrogate endpoints is started by a definition of validity in terms of both trial-level and individual-level association between a potential surrogate and a true endpoint. In another part, we review the main considerable statistical methods being proposed for the evaluation of a biomarker as surrogate endpoints, which have developed and consider how the validation process might be arranged within the regulatory and practical constraints evaluation. In the present work, we propose a new. Bayesian approach to evaluate individual level surrogacy. Deferent variations to prior distributions were implemented for responses with binomial distribution. Then these methods are compared in a simulation study. Finally, we apply and compare the previous and new methodology using a clinical study.
Keywords: Surrogate Endpoints, Evaluation, Individual-level, Prentie’s Criteria, Bayes Factor, Schwartz Cirteria
Full-Text [PDF 573 kb]   (1184 Downloads)    
Type of Study: Applied | Subject: Biostatistics
Received: 2018/11/16 | Accepted: 2018/11/16 | Published: 2018/11/16
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Jalaei S, Faghihzadeh S, Eskandari F, Ghazanfari T. Evaluation of Surrogate Endpoints by Bayesian Method. JSS 2008; 2 (1) :23-49
URL: http://jss.irstat.ir/article-1-637-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 2, Issue 1 (8-2008) Back to browse issues page
مجله علوم آماری – نشریه علمی پژوهشی انجمن آمار ایران Journal of Statistical Sciences

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