Evaluation of Surrogate Endpoints by Bayesian Method
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Shohre Jalaei , Soghrat Faghihzadeh * , Farzad Eskandari , Touba Ghazanfari |
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Abstract: (5650 Views) |
Part of the recent literature on the evaluation of surrogate endpoints is started by a definition of validity in terms of both trial-level and individual-level association between a potential surrogate and a true endpoint. In another part, we review the main considerable statistical methods being proposed for the evaluation of a biomarker as surrogate endpoints, which have developed and consider how the validation process might be arranged within the regulatory and practical constraints evaluation. In the present work, we propose a new. Bayesian approach to evaluate individual level surrogacy. Deferent variations to prior distributions were implemented for responses with binomial distribution. Then these methods are compared in a simulation study. Finally, we apply and compare the previous and new methodology using a clinical study.
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Keywords: Surrogate Endpoints, Evaluation, Individual-level, Prentie’s Criteria, Bayes Factor, Schwartz Cirteria |
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Full-Text [PDF 573 kb]
(1184 Downloads)
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Type of Study: Applied |
Subject:
Biostatistics Received: 2018/11/16 | Accepted: 2018/11/16 | Published: 2018/11/16
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